Let me address those questions...
The Isuzu 4BD2-TC is very similar to the older 4BD1-T, which was a completely mechanical engine. The updated engine does have a kind of "computer," but from what I gather, it's more of a logic system that controls the glow plug timer and the engine warming system, plus a couple other things. The injection pump is all mechanical.
This engine has a proprietary bellhousing and is not compatible with anything but Isuzu transmissions. I've heard reports that older versions of the 4BD1-T from the mid-80s could be had with a Chevy adapter, but only for industrial applications (e.g. generators). Those parts aren't available anymore.
I had my mind set on using the SM465 because of its gearing and size, so I designed an adapter plate. The plate is 13" in diameter and made from 1" thick 6061 aluminum alloy. It converts the metric Isuzu bolt pattern to the Saginaw truck pattern used by the SM465. The aluminum bellhousing in the other pictures came from the automatic transmission in the box truck.
Due to the fitment of the diesel's flywheel, I need to make another adapter to use a Chevrolet clutch. The Isuzu flywheel will still be used for the starter motor. Even with two flywheels, the engine will not be overloaded from rotating mass -- the factory torque converter for the NPR's automatic transmission weighs about as much as my configuration.
Starting with post #51 in the Pirate thread, I go into a lot more detail about the adapter. Another fellow, dieseltim, posted his results there, too. His adapter mates the NV4500 to the Isuzu diesel, but it doesn't use two flywheels. The NV4500 has a slightly longer input shaft that is able to reach the factory diesel flywheel. That wasn't an option for my SM465.
As far as mileage goes, I'd be happy with 20 mpg, but I'm hearing about guys who are getting upwards of 30-35 mpg in their vehicles. (The Isuzu diesel swap is pretty popular for the Land Rover guys, especially in Australia.) The box truck averaged about 12 mpg on the turnpike, but the engine is due for a rebuild with 225,000 miles on the clock. Cruising speed was around 65-70 mph, and I don't think these trucks are geared for economy at those speeds. Minimum BSFC occurs near 2000 rpm, and I'm sure it was operating well above that.